Would you like to always enjoy sex? Strange and even silly question – that is what the majority of men would say as the answer seems to be obvious for them. Alas, in fact, some men dream about having a full-fledged sexual intercourse at least sometimes. Yes, this is impotence or, as it known in medical circles, erectile dysfunction that sooner or later becomes a terrible reality for many representatives of the stronger sex. But don’t worry, we’re not going to scare you as THERE IS a well-tried remedy against impotence! Now you can rely on Viagra Online – Canada may rest assured that every of its man who need a help at struggle with erectile dysfunction will get it really fast!

What is impotence?

Impotence (erectile dysfunction) is defined as the repeated inability to keep up erection that is necessary for sexual intercourse. Both elderly and young men suffer from this dysfunction that can be caused by many different reasons. In elderly men the cause of impotence is often chronic diseases or injuries while for younger people it is more a psychological problem. In this case erectile dysfunction may be connected with psychological injuries in childhood or adolescence, lack of sexual experience, fear of being ridiculed, fear of sexually transmitted diseases, etc.

Other causes of impotence include:
– lack of testosterone in the body;
– damage of vessel walls leading to blood supply disturbance;
– consequences of strokes, diseases and injuries of peripheral nerves and the central nervous system;
– intake of medicines for the treatment of other serious diseases such as gout, cardiovascular and ulcerous diseases, mental disorders, etc.;
– pernicious habits like smoking, alcohol consumption, harmful food, frequent taking sauna, stress and more.

How does Viagra overcome impotence?

Everybody seems to hear about Viagra, but really a few of us do understand how it works and why it truly helps. Contrary to the diffused opinion Canadian Viagra and its analogues affect only blood supply of penis and have no psychotropic effects. This means that the drug can improve potency, but does not stimulate libido. However, physicians have noted that when there is normal erection the desire of sex often comes on its own.

And what does Viagra do to stimulate erection? Viagra has a selective effect allowing to expand penis blood vessels and to increase blood filling of the sexual organ when there is sexual excitement, and thus Viagra contributes to achieving and keeping up erection at the proper level. In addition to effect on the potency Viagra improves the quality of sexual intercourse providing longer duration (time of ejaculation), reducing the time of recreation between the contacts, improving emotional perception of orgasm.

Viagra effect is caused due to the characteristics of its active substance, Sildenafil, which is a synthesized inhibitor of cGMP-specific enzyme, phosphodiesterase type 5. PDE5 neutralizes guanosine monophosphate enzyme which is responsible for increasing nitrogen oxides level and relaxing smooth muscles of penis. If they can’t relax, penis blood filling decreases and erection cannot be achieved. Sildenafil inhibits PDE5 allowing the muscles of penis to relax and stimulating blood flow to the sexual organ. Thus Viagra helps treat impotence in all those cases, when it is related to problems of psychological, vascular and mixed nature.
Keep in mind that today Viagra in Canada is available (click here to see offers) and every man suffering from erectile dysfunction can purchase these magic pills at any time he needs the help. So enjoy sex ALWAYS when you’d like to and say to impotence shut up!

Viagra Wonder Is Still On!

Posted by Viagra Ed On August - 24 - 2012 ADD COMMENTS Subscribe here

The wonder of viagra will never cease! There was the Peruvian viagra, viagra ice cream, viagra to cure jet lag and now the most recent – Viagra Oyster. It’s funny but true that Viagra has remarkably maintained its popularity in spite of being launched nearly a decade ago and facing controversies now and then. Further, many competitors have come and gone but the Viagra magic is still on. In regard to impotency Viagra is the father of all and has influenced the entire world in curing impotency.

No drug has ever been as popular as viagra. The very word Viagra pills online has become synonymous of impotency although there are many other drugs available which even work and last longer than viagra. Though this drug is meant for the use of males only, it is one of the most searched word on the internet and the most spoken about medicine. It has also become the pun of many jokes and thereby helps in spreading smiles and happiness.

Viagra is being popularized again and again through the use of its name whenever a new discovery is made via any drug, drink or food. The use of words such as the “new viagra food,” “new viagra drink,” “new viagra chocolate” etc will never end. Though, the use of Viagra word has greatly elevated the popularity of viagra as an important drug by labeling each and every stuff found to be having the potential of curing impotency, it can also bring it down and tarnish the real image of viagra if the so called drugs or drinks don’t live up their name. Further, it breaches the patent right.

Viagra though is potent of giving satisfying results; it too has limits which should never be overlooked. Viagra should always be taken in consultation with your doctor. Viagra which actually is sildenafil should not be taken along with nitrates as it can even cause deaths. Taking of nitroglycerin patches, nitroglycerin ointment, pills or nitroglycerin ointment or isosorbide pills along with viagra causes the blood sugar to drop so low that it may lead to death.

Therefore, when new things come in the market like the recent Viagra oyster you should not rush to it. It is important to check out the safety measures first. For many people the viagra oyster may be a nice delicacy which can be food as well as a medicine but do you know the side effects? As the oysters were fed on the crushed Viagra and some minerals they are not the same as the natural oyster. Therefore, whenever any anti-impotency drugs or local remedies are discovered do not rush to it until and unless proper research or studies are done on the subject.

Exactly What Is Viagra

Posted by Viagra Ed On August - 23 - 2012 ADD COMMENTS Subscribe here

Exactly what Is Viagra

What’s Viagra?Viagra is an anti-impotence drug with an energetic ingredient sildenafile citrate for remedy of male impotence. Sildenafile citrate relaxes the muscular tissues and will raise the blood circulation to distinct places of the whole body. The usage of Viagra raises the capacity to know and maintain erection on getting sexually stimulated. Adult males taking Viagra have reported an amplified intercourse push, accelerated stamina, and more quickly recharge. Viagra functions together with sexual stimulation to allow receive most sexual satisfaction. Nonetheless, Viagra does not assure security from discovering sexually transmitted well being circumstances, collectively with HIV and Hepatitis.How Viagra will work? Viagra permits countless males with ED to respond to sexual stimulation.

When a guy is sexually aroused, the arteries in the penis loosen up and widen, permitting for even more blood to circulate into the penis. Because the arteries in the penis develop and harden, the veins that typically carry blood away from the penis establish into compressed, limiting the blood move out of the penis. With additional blood flowing in and much less flowing out, the penis enlarges, top to an erection. It is truly to become well-liked that Viagra should not be a hormone or aphrodisiac, it seriously performs exclusively when a guy is sexually stimulated.Viagra DosageViagra is obtainable in the kind of tablet and is meant to be taken orally. Ideally it is to become taken virtually an hour previously than the sexual physical exercise. Even so, Viagra might be taken anytime from four hrs to thirty minutes prior to than sexual activity.

It usually requires thirty – forty five minutes for displaying Viagra’s impression and this impact lasts for nearly four hours. In case you receive Viagra right following an extreme-fats meal (corresponding to fish & chips, cheeseburger or French fries), it could consider considerably for a longer period to start off functioning. Viagra ought to not be used extra than as soon as a day until eventually prescribed by your doctor.

Warnings/Precautions

It’s continually advisable to seek out the recommendation of physician prior to than starting the consumption of Viagra. In scenario you might have the historical past of an coronary heart attack, stroke, or lifestyle-threatening irregular heartbeats inside the last 6 months or have coronary coronary heart failure earlier coronary artery sickness angina high or lower blood stress liver challenges kidney concerns blood complications, like sickle cell anemia or leukemia a bleeding dysfunction belly ulcer retinitis pigmentosa (an inherited circumstance of the attention) bodily deformity from the penis equivalent to Peyronie’s disorder or an issue that could lead to extended and distressing erections, resembling a tumor from the bone marrow, sickle cell anemia, or leukemia or you just take some other medication that contains nitrates your blood emotional stress could all of a sudden drop to an unsafe level and can risk your life.

All these clinical conditions and in addition allergy to sildenafile or any of its components can result in disastrous benefits. So it’s all the time highly recommended to look for the information of your medical professional for adjusting the dosages just after monitoring the treatments detailed previously mentioned.Viagra is not authorized or endorsed to become employed in women. Due to this truth, ladies need to not just take Viagra beneath any circumstances. It moreover not advantageous for males older than 65 a long time apart from they tolerate it in compact doses for these who are delicate to the results of Viagra.Missed DoseViagra may be used as and when wanted and there’s no concept of missed dosage.Doable Side Effects of ViagraEvery medicine has some or the opposite facet result and so does Viagra. It is dependent upon personal to special human being and is usually mild to moderate and do not very last much more time than a few of hrs. Principally these undesirable side results are evident with higher intakes of Viagra.

The commonest unintended effects of Viagra are headache, nausea, flushing of the confront, and upset stomach. In addition there will be some momentary adjustments in coloration vision (resembling bother telling the big difference concerning blue and inexperienced objects or obtaining a blue coloration tinge to them), eyes modifying into delicate to gentle, or blurred eyesight.But when you turn out to become dizzy or nauseated, or have ache, numbness, or tingling in your chest, arms, neck, or jaw all through sexual activity, cease and contact your doctor proper away. You could maybe be getting a severe aspect impact of Viagra, or in scenario you have sudden imaginative and prescient damage or have any of these indicators of allergic reactions like hives issues respiration inflammation of your face, lips, tongue, or throat search emergency professional medical enable without delay. It’s generally highly recommended to cease using Viagra and simply call your medical doctor instantaneously when you have any of these imperative problems like – chest ache or weighty feeling, discomfort spreading to the arm or shoulder, nausea, sweating, common sick feeling irregular heartbeat swelling in your arms, ankles, or ft shortness of breath and imaginative and prescient variations.In uncommon circumstances, males have described an erection that lasts numerous hours. But if this is the situation then you require to identify a doctor without delay if an erection lasts far more than four hours. If not handled appropriate away, everlasting harm to your penis could arise. Heart assault, stroke, irregular heartbeats, and dying have been noted hardly ever before in males taking Viagra. Most, but not all, of all those males had coronary heart matters just before taking this medicine. It’s not doable to determine no matter if these occasions had been instantly connected to Viagra.The www.indianviagra.org online websit providing Viagra for sale can be readily accessed on the online world.

Oral Phosphodiesterase

Posted by Viagra Ed On August - 22 - 2012 ADD COMMENTS Subscribe here

Oral Phosphodiesterase

  1. Inhibitors PDE­5
  2. Pharmacokinetics and pharmacodynamics
  3. Side effects
  4. Safety
  5. Comparison

Phosphodiesterase, as mentioned in the previous  section, is paramount to the breakdown of cGMP  in the SMC. This enzyme is found in several dif­ ferent tissues throughout the body and has been  categorized into 11 families. The family that is  found in corpora cavernosum tissue as well as  smooth muscle and vascular smooth muscle is  PDE­5. As the role of PDE­5 was elucidated in  the 1980s, drugs were targeted to inhibit this  enzyme and increase the NO in SMCs. A result  of this was an unexpected increase in NO in  penile tissue and improvement in erectile  function. PDE­5 inhibitors were first marketed in 1998  with the dawn of sildenafil (Viagra®). This was  followed closely in 2003 with vardenafil  (Levitra®) and tadalafil (Cialis®). As the market  for these drugs has increased, it has been impor­ tant to identify the safety, efficacy, and limita­ tions of these drugs. When choosing a PDE­5  inhibitor for a patient, it is important to know  the onset of action, efficacy, and duration.  Studies usually will define the maximal plasma  concentration (Cmax ), time to reach this plasma  concentration (Tmax ), and the plasma half­life  (t ½). How well these laboratory findings corre­ late to clinical findings is sometimes difficult to  determine and the measuring tool most com­ monly used to evaluate efficacy is the International Index of Erectile Function (IIEF)  domain score.

Viagra®

The most studied of these drugs is sildenafil  (Viagra®). In several placebo controlled, ran­ domized trials, this drug has been shown to  improve erectile function. The pivotal study for  sildenafil was published in 1998, which showed  a clinically and statistically significant improve­ ment in IIEF domain scores for men suffering  from ED for greater than 5 years. The onset  of action of sildenafil is approximately 20 min with a reported  t ½ of 3–5  h and duration of  action as long as 12 h. The important thing  about sildenafil is that it should not be taken  with a high­fat meal because this will decrease  the absorption of the medication. Female Viagra Australia

Levitra®

The FDA approved vardenafil (Levitra®) in  2003 after a study of 805 men with ED showed  a clinically and statistically significant improve­ ment in IIEF scores when compared to placebo. In this study, different doses were evaluated and  men were categorized into mild, moderate, and  severe ED. Approximately 40% of the moder­ ate and severe ED men had improvement with  the highest dose and over 79% of the mild ED  men had improvement. Vardenafil is  quickly absorbed with a Tmax  of 45 min and a  reported t ½ of 4–5 h. Onset of action has been  recorded as early as 10  min [17]. Just as in  sildenafil, it is recommended that high­fat meals  are avoided.

A drug like Viagra belongs to the most sought after product over the net. To stay ahead in the competition that involves many online Viagra vendors, various tools like keywords optimization, back links etc can be found incorporated.

Viagra Australia is main. It is plain logic that everyone who likes to buy Viagra would use the word ‘Viagra’ in his search for the erectile dysfunction drug on-line. Rarely would a person key in a word that is not related to Viagra if he’s planning to buy Viagra. Would you? So, what does a Viagra vendor do, keeping in mind this kind of particular psychological aspect of the buyers? He would try to inculcate in the content of his site, words like Viagra, buy Viagra, buy Viagra online, cheap Viagra, Viagra on the internet, discounted Viagra and a plethora of such keywords that millions of buyers use, while going through google search or yahoo search. And well, they are just one of the few ways to oil google and the search engines to achieve up your site ranking.

Well, what does it all mean? Simply put, an illegal Viagra hawker, who provides you nothing the drug mechanisms, benefits, area effects, dosages, storage information along with vital information that are a ‘must-know’ for a Viagra user can occupy the top rank in Viagra search for google, yahoo or msn, by employing the search engine optimization techniques.

Just check for yourself and you will be surprised at the damage that has been currently done, using the tool for wrong ends. Go through ‘Viagra’ as well as ‘buy Viagra’ search in google and you will find that more than half of the sites that come in the first page have Buy Viagra, Buy Cheap Viagra, Discounted Viagra, Viagra On the internet, Best Price, Best Place to obtain Viagra etc. written all over the page, and yes, they don’t forget to give a link to the pharmacies where you can buy only the best and cheap Viagra.

But, never do they mention the indications, contraindications, drug interactions, area effects, safe drug usage et al. Well, a word of advice, don’t trust them. Have I inserted you in a dilemma? You’ll as well ask me, who to trust and where to obtain Viagra from?

Most people who order Viagra online use it for some special reason or maybe the other; either they don’t have the guts to walk up the counter with a prescription to buy Viagra or you can find no regular pharmacies nearby. Let’s keep aside the case in the illegal Viagra buyers, who buy Viagra without prescriptions for reasons best known to be able to them; I have absolutely no worries about them. As far as my experience goes, it’s not the sites with the buy Viagra, inexpensive Viagra, best Viagra Australia online and the likes plastered all through them that give you the information on the right Viagra dosage, together with an expert follow high. They are no lower than the touts peddling illegal fakes in the roadside; avoid them as you do a plague or an epidemic. Always try sites with authentic Viagra information.

There are many sites that provide instructive and educational information on the use of Viagra. With their latest news, researches, critical and analytical articles, many of these sites keep themselves abreast in the recent happenings in the erectile dysfunction drug market. It is safe to buy Viagra online from the best well-informed vendors, because they know what they are selling, and the effects it contains on your sexual well being.

1. “How does Viagra work?”

Viagra works by increasing the flow of blood into internal areas of the penis. Viagra adds to the effects of a normal body chemical released when the male is sexually aroused. The result is that the flow of blood is also increased into a specific internal area of the penis which temporarily cures erectile dysfunction.

2. “When will a generic be available for Viagra?”

There are some generic erectile dysfunction drugs sold online now. Some ED generic drugs sold are Kamagra, Caverta, Silagra, Zenegra and Edegra.

3. “How do I use Viagra?”

Viagra is used one hour before sexual activity is to be commenced. Viagra is drug sold in tablet form that is taken orally and can only be used once in a twenty four hour time frame.

4. “How to buy a generic for Viagra?”

Online sites that sell drugs have generic Viagra under ed drugs. You don’t need a prescription to buy generic Viagra as you would if you wanted to buy Pfizer’s brand name Viagra.

5. “How can I buy Viagra online?”

Viagra can be bought at many online websites that sell drugs

6. “How to save money on Indian Viagra?”

You can save money on Viagra by buying in quantity. The more you buy, the cheaper it costs.

7. “Does Viagra help with Erectile Dysfunction?”

Viagra was formulated to help men with problems like erectile dysfunction.

8. “Is Viagra the same as Sildenafil?”

Sildenafil is the generic name for Viagra.

9. “Where can I get information on how to use Viagra?”

For complete information on how to use Viagra, your health care provider is the best source.

10. “How many people are taking Indian Viagra?”

No figures are kept on men taking Viagra. In England, 6.5 million tablets of Viagra.

Selective Serotonin Reuptake Inhibitors Selective serotonin reuptake inhibitors (SSRIs) have gained notoriety as a common cause of several manifestations of sexual dysfunction. SSRI-induced ED rather than sexual dysfunction, though, is rarely reported in the literature and is limited mostly to case reports.

Antihypertensive Agents Several antihypertensive agents have been implicated in ED, yet the evidence is limited. Older thiazide diuretic treatments have been associated with mild effects on erectile function.

Many of these studies have limited clinical implications as they were conducted with chlorthalidone, a thiazide-like diuretic. A recent study suggested that beta-blocker-induced ED is likely psychogenic rather than organic. Clonidine is reported to cause ED in both human and animal studies through agonism of central alpha-2 adrenoreceptors.

Statins Statins are HMG-CoA reductase inhibitors that are a commonly used medication for the treatment of hyperlipidemia. Do et al. conducted a study to investigate the association between exposure to statins and the occurrence of ED. The study was limited to males age 18–30. They found a statistically significant association for statins with induction and worsening of ED. Further studies are needed to distinguish the severity of the effect on ED between the many different statin drugs that are currently in use.

In cases of ED and hypogonadism, recent randomized controlled trials suggest that patients who are initially refractory to type V phosphodiesterase (PDE5) inhibitors (sildenafil, vardenafil, and tadalafil) can be rescued by the concurrent administration of testosterone with PDE5 inhibitors. The administration of testosterone alone, without PDE5 inhibitors, has also been shown to improve erectile function in hypogonadal men. Androgen deficiency has been shown to result in penile tissue atrophy, increased adipose tissue within the subtunical region, and severe venous leak resulting in ED. All of these effects can potentially be reversed by the administration of testosterone. A number of distinct pathways of the endocrine system lead to ED when functioning abnormally. Several studies show that hypogonadism of any cause is an uncommon cause of ED.

The role of testosterone and other androgens in the achievement and maintenance of penile erection is controversial due to the lack of standardization in defining low testosterone. A recent study found that the prevalence of “low testosterone” in men with ED was largely dependent on the accepted definition of this disease state. Reported prevalence increased from 7% to 47% for definitions of testosterone level less than 200 ng/dL versus less than 400 ng/dL, respectively.

The role of androgens in erectile physiology as demonstrated in the animal model is to potentiate the effects of neurologic and vascular/ endothelial mechanisms of erection. Although tumescence is possible with decreased testosterone, the quality of the erection may be diminished. Importantly, the efficacy of PDE5 inhibitors is greatly diminished in the absence of androgens. Furthermore, in rats, dihydrotestosterone is the primary androgen responsible for erectile physiology at the level of the endothelial cell. Mexican Viagra Online

This decline in serum testosterone level can be age-related or the result of hypogonadism of any cause. A recently published study evaluated the prevalence of both hypogonadism and depression in men presenting to an ED clinic. They also tested the correlation of hypogonadism and the presence of depressive symptoms. They indeed found hypogonadal men to be more likely to have overt depression scores compared to eugonadal controls. The authors derived the conclusion that depression symptoms are strongly associated with hypogonadism and that physicians should consider the evaluation of testosterone levels in men with overt symptoms of depression.

Testicular Failure In recent years, there has been increasing interest in the study of aging males. Testicular failure increases with age as serum testosterone levels gradually decline. This process is not universal. When it does occur, there is significant variability in the age at the onset and the degree of the androgen decline associated with age.

Androgen Deficiency The estimated prevalence of androgen deficiency among men 40–70 years of age ranges from 12% to 45%. Approximately 481,000 new cases of androgen deficiency are diagnosed yearly in the USA.

Physiologic levels of testosterone support several critical processes involved in penile erectile response, including the maintenance of libido and energy levels, in addition to the cascade of events mediated by nitric oxide leading to arteriolar dilatation and relaxation. Screening for hypogonadism in men initially presenting with ED can help identify these men. Drug-Induced ED Erectile dysfunction is a common adverse effect of a number of drugs, and it often has a great effect on patient compliance.

This subject as a risk factor is lightly discussed here and further discussed in more detail later in the textbook. It is important to recognize that many of the drugs associated with ED are used to treat conditions that are themselves risk factors for ED, thus the interpretation of ED in the setting of pharmacological therapy is often difficult in the clinical setting.

KQ 1. The clinical utility of routine blood tests—testosterone, prolactin, LH, FSH – in identifying and affecting therapeutic outcomes for treatable causes of ED was examined using reports of measurements of serum testosterone, FSH, LH, prolactin, and/or other hormone levels, (but not gonadotrophin-releasing hormone [GnRH], Inhibin, Activin, or Follistim). It was also examined in reports of the prevalence of reversible hormonal disorders in males with erectile dysfunction. The study selection criteria included the following:

  • Source: Primary study report published in English
  • Study design: Any (prevalence studies)
  • Population: Adults (age ≥ 18 years) diagnosed with ED with or without concurrent endocrinopathy (i.e., hypogonadism, hyperprolactinemia, abnormal levels of LH/FSH)
  • Intervention (experimental): Hormonal blood tests (i.e., testosterone/prolactin/LH/FSH)
  • Outcomes: Prevalence of endocrinopathies (i.e., hypogonadism, hyperprolactinemia, abnormal levels of LH/FSH)

KQ 2. Benefits of pharmaceutical treatments (e.g. oral, injections, hormonal, topical, intra-urethral suppositories) in males with ED. To address how patient specific characteristics (e.g. specific symptoms/origin, duration, severity of ED/comorbid conditions) affect prognosis/treatment success for ED patients. Evidence on the following treatment modalities was excluded from this review: Natural health products (e.g. herbals), yohimbine, vacuum constriction devices, and sex or surgical therapies (e.g. penile prosthesis implantation, penile arterial reconstructive surgery). Study selection criteria included the following:

  • Source: Primary study report published in English
  • Study design: RCTs (comparative efficacy and harms studies)
  • Population: Adults (age => 18 years) diagnosed with ED (with or without comorbidities)
  • Interventions (experimental/control): Oral (PDE–5 inhibitors, sublingual) injections (IC, cream)
  • Outcomes: Clinically relevant efficacy measures (i.e., scores for the IIEF “EF” domain, IIEF–Q3/Q4, SEP-Q2/Q3, GAQ-Q1, EDITS)

KQ 3. Harms of pharmaceutical treatments (e.g. oral, injections, hormonal, topical, intra-urethral suppositories) in males with ED. Evidence on the following treatment modalities was excluded from this review: Natural health products (e.g. herbals), yohimbine, vacuum constriction devices, and sex or surgical therapies (e.g. penile prosthesis implantation, penile arterial reconstructive surgery). Study selection criteria included the following:

  • Source: Primary study report published in English
  • Study design: RCTs (comparative efficacy and harms studies)
  • Population: Adults (age ≥ 18 years) diagnosed with ED (with or without comorbidities)